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G Protein-Coupled Receptors (GPCR) in a membrane environment
The Blue Gene Science team at the IBM T.J. Watson Research selected a GPCR for their initial work on Blue Gene/L because these membrane proteins represent more than half the current drug targets and a market of tens of billions of dollars annually. Examples of diseases currently treated with drugs that target GPCRs: congestive heart failure, hypertension, stroke, cancer, ulcers, allergies, asthma, anxiety, psychosis, migraines, Parkinson's disease (source: http://www.predixpharm.com/market_table.htm)
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